As a chronic pain patient myself, I was like holy crap after trying the nanoseurm. Took about 15 minutes for full effect. There is no topical in Colorado that compares to the true relief that I’ve experienced from this product. For years I’ve been a patient with severe pain in search for something that does more than take the edge off! I am thankfully that we have products like Evolve’s nanoserum that will help continue to advance the cannabis industry and prove that there is medical benefit.