Top Notch. I am slim guy (150) and I've been smoking for 2 years. I took ONE of these and at the 50 minute mark, it's been the best I've ever felt for like forever. I feel extremely relaxed and happy and somewhat giddy. I feel extremely up / not sleepy. Your first time, take ONE of these and wait a full 60 minutes. Gage from there - but ONE is great for me!!!