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The Biology of Cannabis vs. Opioids for Pain Relief

July 31, 2017
The Biology of Cannabis vs. Opioids for Pain Relief(GeorgeManga/iStock)
Cannabis and opioids are both known for their analgesic, pain-relieving effects. However, opioids are highly addictive—between 1999 and 2014, sales of prescription opioids in the United States quadrupled, with staggering increases in overdoses. In the healthcare system, 49% of patients seeking treatment for pain leave with a prescription. Because the risk of addiction and overdose associated with opioids is so great, finding a drug substitute with less abuse potential is critical.

Amanda Reiman, manager of Marijuana Law and Policy at the Drug Policy Alliance, defines substitution as a “conscious choice to use one drug (legal or illicit) instead of, or in conjunction with, another due to issues such as: perceived safety; level of addiction potential; effectiveness in relieving symptoms; access and level of acceptance.”

It’s important to take these factors into consideration when determining the substitution potential of cannabis. The ideal substitute will perform better than the previous medication by being more safe, effective, and accessible, while also being less addictive.

Related

Is Cannabis Addictive?

States That Legalized Medical Cannabis Show Decreased Opioid Use

There is already evidence that cannabis is used to substitute opioids. In the United States, total prescription drug spending in Medicare for both program and enrollee spending fell by $165 million per year in 2013 after the implementation of several state medical cannabis laws. The most common reported drug substitution was opioids (32-36% of total substitutions), followed by benzodiazepines and antidepressants.

Related

Is Cannabis Better for Chronic Pain Than Opioids?

Data from self-reported studies show that cannabis is already being used to substitute some prescription drugs, and states with legalized medical cannabis have seen decreases in prescription drug rates. Biologically speaking, though, what makes medical cannabis effective for pain relief and a possible substitute for prescription opioids?

Why Can Medical Cannabis Be an Effective Opioid Substitute?

Opioids and THC have analgesic effects because they block pain signals in our nervous system. THC is a plant cannabinoid, most commonly known for its psychoactive effects and causing the “high” associated with cannabis consumption. The THC cannabinoid binds to the CB1 and CB2 receptors of the endocannabinoid system, while opioids bind to opioid receptors.

Evidence suggests CBD can reduce drug cravings and opioid withdrawal symptoms, which suggests CBD could be an effective treatment to opioid addiction.
Related

What is the endocannabinoid system and what is its role?

CBD is another cannabinoid that is known for its therapeutic effects. It binds to many different receptors in the brain and can lessen the effects of THC. Evidence suggests CBD can reduce drug cravings and opioid withdrawal symptoms, which suggests CBD could be an effective treatment to opioid addiction.

Opioids and THC in combination offer comparable pain-relieving effects compared to opioids alone. This interaction can be used to reduce opioid doses for pain management and slowly wean patients off opioid medications altogether as they switch to cannabis-based treatments.

Related

CBD (cannabidiol): What does it do and how does it affect the brain & body?

Cannabis and Opioids Together Offer Greater Pain Relief at Lower Doses

Several studies indicate that cannabis interacts with opioids and alters the associated pain-relieving effects. When co-administered, patients can use a lower dose of opioids and achieve the same level of pain relief, thereby reducing the risk of side effects and addiction.

Medical cannabis can allow pain patients to take lower doses of opioids

Figure 1: When THC and prescription opioids are co-administered, the same level of pain relief is achieved with lower opioid dosage. This can prevent some of the negative side effects of opioid treatment and allow patients to reduce opioid use. (Photo credit: Amy Phung/Leafly)

Cannabinoid and opioid pain-relieving effects both work by binding to receptors at the surface of cells and setting off a sequence of events in the cell that result in no pain signal release. The parallel mechanisms of action for opioids and cannabis allow for effective pain relief with co-administration.

For these reasons, cannabis is believed to supplement the effectiveness of opioids in pain management. When THC and morphine are used together, for example, the same level of pain relief is observed at lower doses compared to morphine treatments alone.

Related

Vast Majority of Pain Patients Prefer Cannabis to Opioids, Study Finds

If implemented, this treatment method could be effective in reducing opioid use and the associated negative side effects. Patients could start taking smaller doses of opioids to avoid addiction and relapse, since the addition of THC would provide comparable pain relief. This has the potential to effectively wean patients off their opioid regimen. Further research is needed to determine the exact mechanisms of interaction between opioids and cannabinoids, and to investigate new treatment plans for patients seeking improved chronic pain management.

Cannabidiol (CBD) Reduces Negative Side Effects of Opioids

Drug cravings are a major cause of relapse and a symptom of addiction. However, current treatments are often ineffective at preventing relapse events from occurring. Cannabis could be used to effectively reduce drug cravings and the chance of relapse.

CBD could help break the cycle of addiction by preventing relapse and treating withdrawal symptoms.
Related

Can Cannabis Help Treat Painkiller and Heroin Addiction?

Researchers are investigating CBD as a possible treatment for addiction. Animal and human studies show that CBD is non-addictive and reduces drug cravings. CBD could also be used to treat withdrawal by reducing pain, anxiety, and mood symptoms.

Regular cycle of addiction vs. with CBD treatment

Figure 2: CBD treatment can reduce the chance of relapse for those struggling with drug addiction by altering the withdrawal and drug abstinence phases. Symptoms of withdrawal will be treated, decreasing pain, anxiety, and mood symptoms. CBD can promote drug abstinence by reducing drug craving through suppression of the reward system of the brain. (Photo credit: Amy Phung/Leafly)

CBD could help break the cycle of addiction by preventing relapse and treating withdrawal symptoms. With the heavy use of prescription opioids in the United States, this could help treat addiction and drug abuse, reduce risk of overdose, and lower prescription rates of opioids.

Related

America’s Opioid Crisis: Can High-CBD Cannabis Combat Pain and Reduce Addiction Rates?

Possible Solutions for the Opioid Epidemic

With the opioid epidemic in full swing, finding a solution to this problem has become more urgent. The most helpful option would be to implement a drug substitution program, finding something that has comparable therapeutic effects with the least amount of side effects possible. Medical cannabis may be a good substitute for prescription opioids because it has similar symptom-relieving effects, especially for chronic pain.

In legalized medical cannabis states, substituting opioids with cannabis and decreasing opioid overdose deaths have already been observed. Cannabis can be used to wean patients off their current opioid regimen and provide pain relief that is comparable to opioid treatment. There is the potential to fight addiction with CBD, reducing drug cravings and symptoms of withdrawal.  More research is needed to identify specific treatment plans for pain relief and drug addiction, but it’s possible that a mixture of THC and CBD could be an effective medication against chronic pain and opioid drug dependence.

 

Sources:
Bradford, A.C., & Bradford, W.D. (2016). Medical marijuana laws reduce prescription medication use in medicare part d. Health Affairs, 35(7), 1230-1236 [PDF]
D I Abrams, et al. (2011). Cannabinoid–Opioid Interaction in Chronic Pain. Clinical Pharmacology &Amp; Therapeutics, vol. 90, no. 6, pp. 844–51. [PDF]
Reiman, A. (2009). Cannabis as a substitute for alcohol and other drugs. Harm Reduction Journal6, 35. [PDF]
Suzanne Nielsen, et al. (2017). Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis. Neuropsychopharmacology, vol. 42, no. 9, pp. 1752–1765. [PDF]

Ashley Auerbach's Bio Image

Ashley Auerbach

Ashley is a Leafly intern researching medical cannabis. She is also a student at the University of Washington studying Molecular, Cellular, and Developmental Biology with a minor in Microbiology.

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  • Terry

    Well written article Ashley. I am one of those success stories, having completely replaced all the pharmaceutical medications I was on for chronic pain, including fentanyl. It is not a cure, but provides better relief overall, and allows much more functionality with no side effects of consequence. It’s a blessing after several years of opioids, going from near death to a new lease on life at 59. Everyone should be able to grow it in their back yard. Someday…

    • Lisa

      Agreed, very well written article. You took complex information and made it palatable for the masses. Not an easy task, but you succeeded. I am hoping to make the transition from opioids to medical marijuana as well. I live in Oregon where dispensaries are a plenty and I’m under the care of a supportive pain management physician, however neither of these entities are able to steer me in the direction of the “right” strain or dose of medical marijuana to address my chronic pain. I also have the issue of not enjoying the “head high” associated with marijuana. I would welcome some real guidance on this topic instead of the trial by error method I have been using.

      • Terry

        Hi Lisa,
        I’m not a doctor, and I don’t know the particulars of your situation, but I can tell you that strain choice is a very individual thing. In general, make sure you’re trying a CBD blend, usually a 1:1 ratio is a good place to start. If your tolerance is high, take a few days off to reset your system and try again. Once you find the right combination a very small dose should provide some noticeable relief.
        Having said that, it does not work for everyone. If your issue is not cannabinoid related you may get very little relief. Most likely however, there are confounding issues, like diet. If you’re feeding your illness all the cannabis in the world won’t help and neither will the pharmaceuticals. That’s something your doctor likely knows nothing about and may even tell you diet doesn’t matter. Nothing could be further from the truth! Start by watching the film “Forks Over Knives” with an open mind, do some follow up research, and you’ll see what I mean.
        Your car won’t run right on the wrong fuel and neither will your body.
        I hope that helps.
        Terry

        • Two Bears

          For me the best place to start was a 2-1.

          Hawaiian dream and Northern Lights 16-17% THC with 5-8% CBD.

      • tim ashley

        Trial and error is the best way to go,also invest in test kit to make Shure your getting the right combo of the, CBD,thc

    • Two Bears

      Same here. I have Crohns. Everything prescribed by Doctors

      Made me feel worse
      Didn’t work
      Or couldn’t afford it.

      All i take is 11-14 mg cannabinoids a day. Got me out of adult diapers. Dealt with the pain. Almost completely stopped the flares. 3 minor flares, and gave me my life back. Im healthier now than i was before the Crohns diagnosis.

  • massman

    Cannabis is the obvious answer to our opiate epidemic. Unfortunately until it is prescribed initially, as opposed to after the opiods have entered your system, the epidemic will remain. It doesn’t end without cannabis as a substitute. This simple solution remains unchartered thanks to prohibitionist lawmakers and medical professionals who refuse to acknowledge the obvious. Contacting lawmakers and voting out prohibitionists is the only solution for now.

    • Two Bears

      Here in AZ i saw a report that since AZ permitted medical cannabis that opiate abuse has fallen 20%.

      It would be a LOT MORE if three things happened.

      1. The state lowered the MMJ card cost. People on fixed incomes. Are barely getting by. The electricity cost is INSANE!

      2. State approved more qualifying conditions. And pain is not one of them.

      3. Insurance companies picked up the tab for cannabis. Here in AZ 7 grams of good medicine is $90-100. Poor people cant afford it. But insurance and meficaid will provide all of the poisonous pharmaceuticals they need.

      If insurance and meficaid picked up the tab the cost would be less and people would get better relief.

      An example of Pharmaceuticals vs cannabis.

      My cousin and i both have Crohns disease.

      My cousin has the VA and Medicare.

      The VA and Medicare picks up $1200-$1500 for his medicine.

      I dont have insurance. I get shatter and make a tincture that is 55-62.5 mg/ml.

      I keep two strains going all the time (Jilly Bean and Tangistan currently) every week i switch strains so i can keep my tolerance low.

      With micro dosing 11-14 mg cannabinoids a day. My medicine is only about $30 a month. And havent had a flare in almost 6 months.

      • TweetyBird

        Not sure what you mean that pain is not an indication for medical marijuana in Arizona. I was approved immediately with a diagnosis of chronic migraine/cluster headaches.

        Other than that, your comment is spot on. The $150 annual fee is ridiculously high. As for the cost of cannabis, shopping around helps a lot. An ounce of Blue Dream is $150 at one local dispensary, and $350 at several others.

        • Two Bears

          You dont get it. Migraines yes. Chronic pain that goes on and on.

          A friend J. Anderson was hit by a hit and run drunk five years ago.

          He has tried twice to get an MMJ card in AZ, and has been rejected both times. The man is in intense pain. Never mind the titanium rod and six screws in his back. So he is on opoids sick all the time from the opiates.

          • TweetyBird

            Sorry about your friend, but chronic pain IS one of the indications for medical marijuana in Arizona. It says so right there on the application form the physician fills out.

          • etowah

            Maybe I’ll move to AZ one day. My wife is tied to work here for now. Will they allow a small amount of opiates along with a little MJ? That is the secret for chronic pain and resulting ADD, I think. Chronic pain and opiods will rule your life and take away all your desire to do anything. A little weed will cure that!

          • TweetyBird

            I think that depends on the doctor. Mine will give me a prescription for 100 Percocet a year, though since I started using cannabis for pain, that now lasts over 2 years. If I had to choose, I’d definitely pick marijuana over opioids.

          • W H

            You seem to be one of the small minority here and on other MJ sites, who grasps the benefits of small amts of well-selected opiates in combination with MMJ. Well-selected and well-managed, this combo can be sort of like 2+2=5. When the MJ crowd leans to think in terms of milligrams and in terms of the active cannabinoid (THC, CBD, maybe others in the future) we’ll get more rational discussion.

          • LLP2112

            Good luck getting opiates anywhere – doctors are too terrified of the DEA to write them. The ONLY reason I got them when my damaged ankle collapsed and I was in excruciating pain, is because I am a hemophiliac meaning I cannot take any NSAIDs, and my hematologist wrote a very stern letter to my doctor demanding that he prescribe them. He finally did, but without that I’d have been on my own. This refusal to prescribe by doctors is EXACTLY why people in desperation turn to heroin and other street drugs.

          • This is right

    • Jef Miles

      I am a pharmacist, and I believe that the majority of health professionals need to unlearn some of their belief regarding the safety of cannabis and take responsibility for the damage to society attributable to mismanaged opiate “treatment”.

      • Denise Martin

        Agreed!!! We need change!!!

      • W H

        You are correct, but you are also over-simplifying. As a physician who deals with this stuff all the time, I experience the ignorance of my colleagues daily. But I also experience the ignorance of pharmacists. Both groups have, in effect, “drunk the kool-aid” of mainstream media histrionics coupled with the cold cynical hand of corporate pharmaceutical industry steering of an out of control DEA and others. Pharmacists, in my experience have been fed such a line of BS by their masters that they have become the unwitting accomplices in fostering this nonsense. The result is under-treatment of bona fide pain by the one group and rude insult of the patient by the other.

        As for the damage to society from opiates, you also appear to have drunk the kool-aid. Doctors have been writing fewer opiate prescriptions since 2010. We grasped the issue long ago. Some grasp it better than others. Opiates are simply a tool that has to be well managed. Studies continue to demonstrate that well managed opiates are rarely, and I do mean rarely, the cause of opioid abuse, addiction and overdose. The “opioid epidemic” and the spike in overdoses has been largely the result of a market for dirt-cheap fentanyl and its congeners mixed with higher grade and cheaper heroin flooding the country from Mexico. The solution to this is obvious, but more complex a discussion than space permits here. The overly simple answer is to abolish the DEA, get a check rein on Big Pharma and spend a fraction of that money on education and hones media reporting. Don’t hold your breath.

        • Rose Grossi

          Thank you! The voice of reason! I am in serious pain, there are no medications to treat my autoimmune disease as it’s a rare/orphan disease and I am unable to tolerate any type of NSAID’S due to the ulcers this autoimmune vasculitis has caused throughout my GI tract. For many years I was left in a prison of pain while trying to be a single parent to 2 children who suffered from my suffering. Until finally a doctor who had compassion wrote me a prescription for fentanyl patches and for the first time in 5 years I was able to get out of bed and go to the bathroom without the overwhelming pain, I then went to work building up the muscles that had wasted away from years of disuse and until the DEA & state medical board started threatening my doctor he kept me on just enough to allow me to participate in the world again, unfortunately it was more than the magic 90 mme and so now I am in pain more often than not and once again secretly wishing I wasn’t a parent so I could put an end to my suffering without causing serious distress for my children. I feel like the legalization of marijuana has contributed to the DEA’s newest drug war and doctors are easy picking for civil assest forfeitures! Illegal fentanyl is a much harder target than the doctors they’ve required to make public their prescriptions and then they can easily go after say the head of HHS of Michigan for keeping 10 patients who have verified painful diseases and need opiates in higher doses than the artificial set levels by the Prop fenatics! I know one thing articles like this written by a person who has never experienced pain in their lives and regurgitating the same crap the DEA has spewed about the dangers of marijuana in a marijuana publication is so mind boggling hypocritical that it defies reason! Yet you can bet they see the years of untruths and outrageous lies by the DEA and our government about marijuana perpetrated against it’s citizens who have suffered great injuries as lies ment to control the populationand perpuate their jobs! Yet they’re perfectly fine with demonizing and destroying the lives of thousands of chronic pain patients who are barely able to function only with the pain relief of opiate medications and they don’t think that the DEA is untrustworthy this time!

      • LLP2112

        As a now-former chronic pain patient, I can tell you the problem with physicians it NOT over-prescribing or mis-prescribing opiates, it is REFUSING to prescribe because they’re terrified of the DEA making an example out of them. Refusal to prescribe adequate pain medication is why desperate people in pain turn to heroin and then overdose and die, and that overdose is reported broadly as an “opioid death” and legitimate pain patients are further negatively affected by it.

        As for me, 5 years of opiates = no problem. I took them starting with weak Tramadol gradually increasing to the highest dose over 5 years. Post-op was 5 days of strong IV hydromorphone in the hospital, plus oral oxy. Then at home it was 2 weeks of high-dose regular oxycodone every 3 hours and oxycontin every 12 hours. I experienced NO “high” and had little difficulty quitting. That’s because I didn’t try to abuse them, I didn’t mix them with booze or other drugs like street users do, and I took them as prescribed. Sadly, the people who choose to abuse drugs (and it IS a choice), ruin it for those who legitimately need these drugs. Now we have elderly suicides on the rise JUST because doctors won’t give them the pain meds they need to not live in a state of medieval torture.

        • Les Henderson

          Ditto

    • W H

      Sorry, you have muddled the concepts of opioid refractoriness that occurs with chronic use, and addictive personality disorder. But then, so have the vast majority of people who think they understand this complex issue. Your suggestion that simply substituting cannabinoids for opioids, while appealing, is also simplistic. They are different. They both have applicability. They often work very well together in much reduced doses. But not all people respond the same to these medications. Also, what is severely lacking is any concept of dose response. you have to select the correct medication and the correct dosage.

      • LLP2112

        Agreed to some degree (The late Allen Carr exploded the “addictive personality” myth but I won’t go there). In any case, opiates (“opioid” is a fake news word and not the proper medical term), worked very well for me for both pre-op pain for a few years and post-op pain. In other words, opiates have a strong pain-killing response in me without any “high” ever experienced. MJ on the other hand is very weak to my system – it takes extraordinary amounts for me to feel much while a good strain will knock friends on their ass after just a couple of hits. My wife will be on her ass after 2 hits of a strong Indica but I need two bowls for the same effect. So yes, everyone is different, everyone’s body chemistry reacts differently to the pharmacology of various drugs, and so on.

        • Les Henderson

          Agree

    • LLP2112

      First off I enjoy cannabis and support legalization, However, having been through a total ankle replacement, there is NO WAY any cannabis strain could have treated the intense hellish pain, both before surgery after the ankle had collapsed which I suffered with for a month, then the post-op pain which was totally unbearable even in ultra-high dose oxycodone. And no, I’m not an addict, they were no problem to quit. (Unlike smoking or drinking.) While cannabis has its medical place, opiates will always be the gold standard for pain relief. Also understand that opiate abuse includes mixing them with booze, other drugs (especially benzos), and so on. Legitimate opiate users like I was don’t have all those addiction and abuse problems when we take the drug as directed.

      • Les Henderson

        You post is the best post I read a out opiates.
        Thank you.

      • Christina King

        I agree that the opiates will now than likely be the gold standard for the worst of the worst pain relief. However, I myself was addicted to opiates for about 6 years, beginning in October of 2008 after surgery. I found myself not only needing them for the pain relief, which was honestly my own mind mimicking pain so I would take more and increase the dose (or just take it sooner, then sooner wasn’t soon enough). I was also wanting them to forget about issues that kept rearing up. ln my worst I was taking ROUGHLY 15-25 Percocet 10mg a day. Generally about 4 at once, starting within moments of waking up. Every single day, until May 2013.. Thank God I only had one overdose . Without that happening tho, I know I would have gotten much, much worse.
        That all being said, I have to disagree with the comment that opiate addiction also includes moving with alcohol and other drugs. No, I never had any alcohol OR other drug, not even marijuana, when I was taking opiates.
        It’s not a person’s CHOICE to become an addict. I didn’t set out to see what that like was like It was a matter of my brain chemistry and make up that would say to me and nag on me always repeating : “Hey! Hey, yeah you!! You notice how i too that pain right away from you right?!! Well, do you know I’m why you feel so light, content, warm and fuzzy?!? Well, I’m going bring that achy pain right back, and it’s gonna be worse. So instead of going thru that misery why not just take another pill or two now to avoid it all ?!? Yeah, that’s what I thought, … I knew you had it in ya!”.
        I was diagnosed with addictive personality disorder. Many addicts have past trauma, PTSD or other mental health issues that go unattended to because the patient is alreadyspeed medicating.
        Please, don’t assume that alcohol and other drugs are indications of an addicted person.
        We are all on the same side here regarding the thought that marijuana needs to be used either in conjunction with or instead of opiates.
        Sorry if this felt hi jacked by or from anyone, never my intent….
        Thanks

  • Deanna Gibbons

    Not EVERYONE s PAIN IS THE SAME!!! SO NO TREATMENT IS FOR EVERYONE!!!

    • Two Bears

      Thats true. I have two friends so allergic to cannabinoids they have to carry an epi pen to keep them from anaphalactic (SP) shock.

      • Deanna Gibbons

        I was Hit & ranover By A Car In 1997. I just had Neck & Back Surgery. Now I Have Severe Nerve Damage! I wish I Could Just Go Get Some Weed & Everything Would Be Better! But The Last Time I Had Anything Like That. I Had A Seizure. So. Plus My Pain Is Way Beyond That… I Am Happy For The People That It Helps …Like This Morning, I woke Up & Could Hardly Walk Again.. Like Before. Like I Had All This Done For Nothing! And Gained Nerve Damage! Ughhh!! Feels like Someone Let loose A Baseball Bat On Me. I Dont Expect Anyone to Expect To Understand… But Thats How I Feel.

        • Donna Morris

          I do understand! I too have been in a severe car accident in 1995. I died more than 3x, but I broke my back 5x, my pelvis 4x, my hip, my rib, which punctured my lung and almost killed me. I required 8 pints of blood. I had a severe concussion. My internal injuries were so bad they told my family that I wouldn’t survive. I was 6 months pregnant with my second son. He died the day after the accident because of blood loss. I recovered good as new for 10 years, then the pain hit. Arthritis. They told me I would get it when I got older- but I thought at 70-80 yrs.. Not at 42. I’ve suffered horribly for 13 years now. With no insurance the only thing I come get was pain medication. Which is not enough. I had a hip and knee replacements last year. In a month, I will get my other hip replaced. You should join the FB groups who deal with chronic pain they are a constant source of kindness, help and support. Good luck. I’d like to know if anyone has used CBD for degenerative arthritis?

  • Open Minds

    What is usually the root cause of most pain? Inflammation. It turns out THC is a very potent anti-inflammatory. This is where cannabis can really make a big difference in fighting pain and addressing the underlying issue causing the pain.

  • Patrice Canniff

    I’m in my 50’s and was a part of a Federal drug study using medical marijuana. It was amazing the relief from my pain I received and cut back to using little of my opoids and muscle relaxer. This was a few years ago but couldn’t understand why this was not approved and especially I was not allowed to continue once the study was over thus, once again, I am enslaved to my opoid, which doesn’t even really totally help, it just takes the edge off enough so I can think and get around the house. Once I was active and now I’m home. Going out for doc appts only. I’m tired of govt. and bean counters telling my doctor what he or she can do. What is the purpose for anyone to spend at least a quarter of a million dollars, but can’t treat their patients without the government telling them that they know how to do a better job. There are always a few bad doctors but that can and are dealt with, just as was done in the past. Opoids have been around many years, maybe the reasons for the immense amount of addictions and overdoses can be stopped and be summed up
    1-soooo many studies over sooo many years has shown medical use of marijuana to be safe, nonaddictive, you can’t overdose on it, not an opoid and it is not a gateway drug. Never had been. So, start allowing pain specialist to start dispensing as a spray or other methods that work as a first medication before opoids are introduced.
    2-You can make statistics say anything you want to show when you have an agenda, and your audience is unaware. Opoids overuse, abuse, etc. now includes heroin, meth, cocaine, crack and other disallowed drugs. So, this is a way to get an agenda that doesn’t show the breakdown by percentage by population. Former VP of Finance, I can say this to be true.
    3-In my mother’s day kids were taking their parents valium. So, this issue of abuse and overuse is not new. We have the technology for fingerprint recognition. Want to curb kids getting into meds or someone taking too much, using fingerprint recognition on the bottle will only dispense the amount at the correct time. This is easier than what you think. Plus it forces you to use only one local and one mail order pharmacy. If any company would like hear more contact me.
    4-Then we can save a lot of bucks all around, and physicians back to doctoring.

  • Joe Salazar

    Well unfortunately I am one of the are patients unable to take CBD or thc I have extremely savere headaches. Which are directly in relation to the cannabanoids. So I am stuck with the opiods. However I do not seem to be getting addicted to them. And I have used them for over five years with exceptional success. Still using the same dose as I started on. Have never needed to increase the dosage. So there seems to always be an exception to all the rules and as long as we are all treated, as individaul, I see no complications to the weed vs the opiates. I would choose it other options if they worked. As I have tried many. With little result, and plenty of side affects. As long as what I’m doing and using is working at this point I see no reason to switch. And dump the apple so to speak. I hope there will be more breakthrough in the future and maybe better treatments for SCI and nerve pain associated.as it is probly one of the hardest to treat of types of pain. Considering there seems to be no apparent reason for the pain.

  • kristine08

    It helped me wean from 140MGS of Oxycodone a day, to 30MGS total in a day.
    Takes the shakes away, the anxiety, and dulls pain & spasms.
    I use a Sativa crumble/wax & Hybrid/CBD 1:1 vape oil cartridge in the day, so I am never sleepy.
    I am able to fall asleep using the INDICA Vape Oil Cartridges.
    I keep it next to my bed. 3-4 puffs and I slip into the most delicious sleep ever.
    I use to take 1MG of Klonopin at bedtime, and now I am down to .5mgs (I bought a pill splitter)
    Hoping to get off the incorrectly prescribed benzo at some point.
    WHY are physicians not getting in trouble for prescribing so much Xanax & Klonopin?
    Harder to get off then HEROINE, yet no public outcry about this?
    It is suppose to be for panic attacks (PRN) not a daily dose.

    • CycleAZLindyB

      I don’t understand why it’s all the prescribing doctor’s fault. The patient is the person who fills and chooses to take the pills. I am also prescribed xanax for anxiety and take it very sparingly. I’m not the least bit dependent or addicted.

      • Deanna Gibbons

        EXACTLY!!!!

      • W H

        Well stated. it is a human trait to blame others for our own failures, including our failure to take responsibility. That doesn’t mean the person with the perceived need for xanax couldn’t benefit from more evaluation of the causes for their stress induced insomnia.

      • Rose Grossi

        Because we live in a world where people are unwilling to accept any type of personal responsibility! Oh the drug addicts are dying from shotting up heroin laced with fentanyl, test kits exist, drug addiction clinics and medication to get off the drugs exists, psychologists exists to help with the trauma that started your desire to escape life, heck go use some psilocybin for that depression and anxiety instead of the heroin and meth! But no we’re going to blame granny for needing pain medication so she can get ato the bathroom and not defecate on herself leading to a life of pain in the nursing home because she can’t take care of herself and she is too much work for the family. It’s not the drug addicts fault or the heroin or illegal fentanyl and alcohol and benzodiazepines they stole it is the doctor who is still compassionate and grandma’s fault because the little bast@&d stole her medication and liked it!

    • Deanna Gibbons

      I HAVE TO HAVE MY ZANAX> MY DR> WONT PRESCRIBE ME Me Anything Over 1 Mlg 60 A Month. Even When I asked For A Higher Dose. I Cant SLEEP WITHOUT IT!! It Shuts Off The Tape Recorder off in My Brain.

      • etowah

        Klonopin is better for sleep but is really hard to get free of if you want to. For more Xanax you’ll have to go to a psychiatrist. The regular doctor has limits that gets the government looking at them. That’s why they won’t give you more.

    • Two Bears

      Congrats. Glad you got relief.

    • W H

      “WHY are physicians not getting in trouble for prescribing so much Xanax & Klonopin?”

      This is far too simplistic. As in most issues that are incompletely understood, you seem to be painting all members of a profession with the same brush. These drugs are stated to be “safe and effective” by the FDA. Patients demand them. So, physicians prescribe them. When was the last time you saw a doctor trying to sell you benzos? Never. That doesn’t mean that a number of physicians couldn’t benefit from better education. However, many doctors spend hours every day and week explaining to patients the benefits of eliminating or reducing these drugs. Substitution of cannabinoids can be an excellent alternative in many patients. But not all. And the “detox” from high dose benzos is far more complex than most physicians and certainly most of the public, understand.

      You seem to benefit from some unknown dose of THC/CBD. Fine for you. But over-use of cannabinoids and in an uncontrolled fashion, which you seem to be doing with the inhaled version, can also have deleterious social and intellectual consequences.

  • Two Bears

    The reasob cannabinoids are better for pain than opiates is in three parts.

    1. Cannabinoids are almost an exact copy of the neuro transmitter Anandomine (molecule wise).

    2.cannabinoids tap into the Anandomine CB1 and CB2 receptors

    3. There are about 10 times as many Anandomine receptors as there are opioid receptors.

  • colvin

    I wonder what my sister’s life would have been if not for the timely intervention of Peter Hurt, who came to the rescue of my sister life when the Doctors here in Tallahassee, FL gave her just few months to live.I really appreciate brother Tulip $ sister Elisabeth for their timeless effort to get a cure for our sister by searching over the internet and giving me doctor Peter’s phone number after several effort to get a cure for my sister. Just last week the doctors who once said my sister only have few months to live just confirmed she is now cancer free of the brain after 3 months of using Doctor Peter’s CBD/THC Oil .Thank you so much brother Tulip/sis Elisabeth and Doctor Peter Hurt for saving my sister life phone #(804) 537-091

    • Rose Lemar

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      • peterhurt035@gmail.com

        got some medical marijuana and Cbd/Thc oil from Dr peter hurt via Phone number +18045370917

  • Amanda Page

    How to sensibly buy LEGAL cbd oil online? Because I got a letter saying customs has confiscated my package two times already and I’m pissed.

  • etowah

    I really wish I could use a little marijuana along with Norco. I know I would be able to take less opiods and feel much better but I’m afraid they would cut me off and leave me in pain. It really is stupid that we can’t use a little of both and feel better. It’s like… if something makes you feel better.. it’s EVIL. I don’t get it.

  • Nathalie Burnett

    How to sensibly buy LEGAL cbd oil? Because I got a letter saying customs has confiscated my package two times already and I’m pissed.

    • Rose Green

      It helps if u live somewhere with a dispensary. Most of em here in FL deliver

  • LLP2112

    I had a total ankle replacement one year ago this week. While I enjoy cannabis and support legalization, there is NO WAY IN HELL that even the best medical strains could even TOUCH that pain level. Not even close. I was on a weak opiate, Tramadol, for five years. (Opiate is the real medical term – “opioid” is a media-invented fake news word.) After surgery I was on a very high dose of both Oxycontin and Oxycodone. Then back to Tramadol as pain subsided then went off them entirely. Stopping them after 5 years? Mild withdrawal, mainly intensified pain sensation that would cause unexplained backaches, but that’s about it. Much easier to quit than cigarettes or alcohol. While cannabis has its place, the potency simply isn’t there to treat severe pain. Moderate pain? Sure. It would have worked 5 years ago when I started Tramadol, however, Tramadol gives no “high” or impairment while cannabis would have affected my driving, my work as a business owner, and so on.

  • gomez K
    • Sandra

      Sports injuries and car accidents have meant years of chronic pain, chiropractors, acupuncturists, and physical therapy, which have all not helped. But only CANNAPHARMAS 50/50 Oil provides total pain relief and restores complete range of motion.

  • SAINT Brand Cannabis
  • Joe Citizen

    CBD, as an alternative to low cost opioids, is currently too costly at $60 for 1000mg.

  • Rose Grossi

    I’m sorry but marijuana is not a replacement for prescription narcotic painkillers! First myself like quite a few others who live with the chronic pain from incurable diseases that in many instances don’t even have a medication to treat them depend on opiates to function and not be bed ridden invalids that our families have to put in rest homes if we do not commit suicide because of the unending unendurable pain that we suffer without opiates. Second prescription medications for the relief of pain are not fueling the opioid problem, nor are they responsible for the deaths associated with the use of illegal street drugs. That’s heroin mixed with fentanyl and whatever else the person can get their hands on, usually alcohol which then creates a fatal situation where they die from drug induced asphyxiation. So if you are using herion by all means switch to marijuana and don’t mix your drugs. Back to marijuana for pain relief there are many people who have tried marijuana and found themselves in severe pain from the marijuana myself included. Instead of having any pain relief I was in some of the most excruciating pain I have ever felt and eventually I was hyperventilating because of the pain and it took hours to get it to stop, all of that from a tiny puff of marijuana! I wasn’t one to give up easily and tried multiple types and of course much lower controlled doses but then I researched what was wrong and learned that people who use marijuana need more opioids when they were injured than people who didn’t use it! So while I don’t doubt that it might make some people forget about the pain much like meditation I also can assure you that we need our pain medication and don’t deserve to be forced to choose between a lifetime of unending pain or suicide! Many have chosen suicide because of the forced tapers and patient abandonment caused by the DEA criminalizing pain and the only medication that truly relieves it for those who are in pain. And finally the addiction rate is less than 5%, if you don’t become addicted upon use the amount of time you use it doesn’t matter because opioid addiction is a genetic disorder and it’s been stable at around 1-3%since it was studied at the end of Vietnam in veterans returning home who had access to pure heroin/opium and simply walked away with no addiction except the few who were genetically predisposed. So enough of the bs lies about opioids thats destroying lives just like the lies about marijuana did before it!