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Study Finds Epilepsy Patients Feel Better After Daily CBD Regimen

December 12, 2017
(AbzalovAyrat/iStock)
WASHINGTON DC — Patients with intractable epilepsy in Alabama felt better overall one year after initiating a daily cannabidiol (CBD) regimen, according to a study presented here, despite also reporting declining social support and more stressful events over the course of the year.

Epilepsy patients started taking daily doses of CBD. One year later, a significant number felt better.

The state-funded study did not directly assess CBD’s impact. “I can’t say that” CBD was a factor, said lead researcher Barbara Hansen, now a sociology professor at Henderson State University (Arkansas). She did confirm that every patient in the study was indeed administered CBD, when she spoke to Leafly.com at the American Epilepsy Society annual meeting earlier in December.

Intractable epilepsy is “a seizure disorder in which a patient’s seizures fail to come under control with treatment,” according to the University of Rochester Medical Center. The seizures are also referred to as “refractory” or “uncontrolled.”

Researchers with the University of Alabama at Birmingham (where Hansen was then a doctoral student) enrolled patients in April 2015 in an open-label study, distributing 100 mg/ml CBD solutions. The participants took initial doses of 5 mg of the solution per each kg they weighed every day, via twice-daily spoonfuls. Patients could increase their daily dosage by 5 mg every two weeks, up to a maximum of 50 mg per kg per day.

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They completed two quantitative psychosocial surveys — The Interpersonal Support Evaluation List (ISEL) and Stressful Events Index (SEI ) — and a simple measure asking them to assess their overall health on a scale of 0 (“poor”) to 1 (“good”) at baseline, and again either one year later or when they removed themselves from the study.

After one year, 77.4% of participants reported feeling good, versus 73.3% at baseline—a difference that was statistically significant. That reported increase in good feeling came about despite the fact that many participants noted a decline in social support and an increase in  stressful events in their life over the year. Participants overall reported a 2.3-point decline in ISEL scores on average (33.9-31.6) and adults reported an average increase of 0.29 stressful events (0.57-0.86). Children, however, reported 0.86 fewer stressful events (1.82-0.95). These figures were all statistically significant.

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Stressful Lives, Better Feeling

“People (overall) felt better after one year, even though they didn’t feel as supported socially and the number of stressful events increased,” said Hansen, a former social worker. She declined to assess CBD’s potential role, noting it is not her expertise.

At the meeting, the researchers reported data captured between April 1, 2015, and June 1, 2017, from Alabama-Birmingham and Children’s of Alabama medical centers. Primary caregivers completed the questionnaires for patients unable to do so.

Participants’ age ranged from 1-year-old children to 62-year-old adults. 52.6% of participants were between children or teens (up to 19 years old), 51.9% were women, and 85.2% were white.

Some participants dropped out of the study without completing follow-up assessments. Researchers reported baseline data on 135 patients at enrollment, while the one-year results concerned 62 of those patients.

This Alabama project continues, Hansen said, with researchers planning to examine specific factors of the ISEL and SEI “to identify particular social supports and stressors that may be associated with overall perceptions of health,” according to an abstract researchers presented at the conference.

GW Pharmaceuticals is providing the CBD solutions at no cost to the state, researchers reported.

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Ryan Basen's Bio Image

Ryan Basen

A writer living in Washington, DC, Ryan Basen covered medical cannabis, sports medicine and health policy for MedPage Today. He has also written for the Charlotte Observer, the Washington Post and the New York Times.

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  • twcooper@charter.net

    Was the CBD natural or synthetic?

    • twcooper@charter.net

      GW Pharma would use a synthetic CBD.

  • gomez K

    Yes Epilepsy Patients Feel Better After Daily CBD Regimen. I will use this Media to thank CANNAPHARMAS for their help on this site. My son is totally free from Epilepsy grace to CANNAPHARMAS for their timely intervention. You can visit them and feel support talking to qualify doctors