THCA and CBDA Crystalline: Cannabinoids at Their Purest

(Julia Sumpter/Leafly)

Purity and potency are driving forces in the cannabis concentrates market. Chemists and engineers conducting research and development in this field have been hard at work creating concoctions that consistently push the boundaries of what can be done with cannabis extractions and isolations.

One question more curious extract consumers ask is this: Can pure cannabinoids be isolated and packaged for consumption? Yes, they can. Extractors are now delivering a crystal-like isolate product composed of THCA and CBDA that is often referred to as “crystalline.”

RELATED STORY
Dissolvable Cannabinoids: A New Frontier in Cannabis Consumables

What Is THCA and CBDA Crystalline?

THCA & CBDA crystalline cannabinoids
THCA crystalline from DabX, dunked in Scott’s OG terpenes. (Julia Sumpter/Leafly)

Tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) are the two most prominent cannabinoids found within the trichomes of living cannabis plants. Both THCA and CBDA are precursors to their pharmacologically active, commonly consumed analogues, THC and CBD. As a living cannabis plant cycles through the final stages of senescence, these unstable cannabinoid precursors slowly decarboxylate and become active. Once a plant is harvested and dried, various forms of heat application can also decarboxylate cannabinoids into their active compounds.

Isolated THCA and CBDA are the purest form of concentrate available, with potencies topping at around 99.9%.

Cannabis contains hundreds of active and inactive compounds that take on many shapes and structures on a microscopic level. THCA and CBDA are both similar in that their molecular composition resembles a crystalline formation with rigid and latticed structures. When completely isolated and in visible quantities, these compounds look a lot like snowflakes or crushed rock salt.

RELATED STORY
Cannabis Oil Distillate: A Different Kind of Concentrate

Isolated THCA and CBDA are the purest form of concentrate available, with potencies topping at around 99.9%. This means that there are no traces or terpenes, flavonoids, fats, lipids, or anything else from the raw plant. For this reason, isolates contain little to no flavor, color, or aroma.

The specific process of creating crystalline is a well-guarded proprietary secret, but processors have divulged enough information to give us a general idea of how this complicated preparation is conducted.

How Is THCA and CBDA Crystalline Made?

The process of isolating and collecting cannabinoids begins with an extract. Aside from primary acidic cannabinoids such as THCA and CBDA, these extracts contain a number of other components that range from terpenes and flavonoids to fats, lipids, and a host of other particulates. In order to remove these compounds and isolate the cannabinoids, a series of washes and separations must occur.

The first wash is typically done with the popular extracting hydrocarbon hexane as well as acetic acid (think super-concentrated vinegar). Once mixed, these chemical solvents help to strip away plant particulates and impurities. In order to remove these chemicals, the slurry must be fed into a rotary evaporator, sometimes referred to as a “rotovap.” Rotovaps are designed to gently separate solvents from compounds through the process of slow heat introduction combined with pressure and rotational motion.

RELATED STORY
The Art of Extraction, Part 6: Experts Talk Cannabis Extracts

Once this first step is complete, the remaining cannabinoids must undergo further isolation through a separation process called “preparative chromatography.” In short, this form of chromatography is used to separate compounds by passing it through various mediums at different speeds. To isolate cannabinoids with this method, more chemicals are introduced which must be filtered out through yet another round of rotary evaporation.

Both THCA and CBDA have medicinal properties despite being inactive, and can be supplemented in their raw form through several methods.

Crystalline THCA and CBDA are considered inactive insofar as they do not have the same psychotropic properties as THC and CBD if ingested in their current state.

The final stage in cannabinoid isolation is to prepare the product for human consumption. At this stage, all that is remaining are pure cannabinoids and a minuscule amount of lingering impurities. These remaining particulates must be removed with solvents such as methane and pentane through individual mixing and separation phases. Each solvent is added and subsequently removed by use of the rotovap.

Once the final separation is complete, the remaining product will be 99% pure crystalline cannabinoids.

How to Use Crystalline THCA and CBDA

In order for crystalline THCA to become active and deliver intoxicating effects, it must be heated. However, both THCA and CBDA have medicinal and therapeutic properties despite being inactive, and can be supplemented in their raw form through several methods.

RELATED STORY
What Is THCA and What Are the Benefits of This Cannabinoid?

Crystalline cannabinoids work well for oral ingestion as they can be prepared into foods and even portioned into pills or capsules. Because these cannabinoids are so pure, they are easy to dose.

Those who wish to rapidly activate their crystalline cannabinoids often do so through vaporization and dabbing. By dabbing or vaporizing THCA, decarboxylation occurs near instantaneously, breaking down the inactive, acidic cannabinoid into THC. CBDA crystalline may be vaporized and dabbed as well, although activated CBD is not intoxicating. However, it can still be used to harness medical benefits and temper the intoxicating effects of THC.

Crystalline THCA and CBDA have very little to offer in flavor, which is why many producers enhance these pure extracts with additional terpene blends. The combination of terpenes and cannabinoids can provide a more robust experience, not only by adding flavor, but also through more nuanced effects.

RELATED STORY
How to Dab Cannabis Concentrates

As you can see, crystalline cannabinoids provide benefits that are not available with traditional concentrates and extracts.  Their only downside? These products are difficult to produce and few manufacturers have dialed in a consistent recipe for preparation. This makes crystalline products very expensive in the few markets they are available in.

If you’re lucky enough to get your hands on some crystalline cannabinoids, share your experience and photos in the comments below!