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The Top CBD Cannabis Studies of 2017

December 28, 2017

The Top CBD Cannabis Studies of 2017

The past year was important for proponents of medical cannabis. Those seeking to remove cannabis’ Schedule I status are now armed with even more evidence for its medicinal and wellness benefits from a combination of human and rodent studies. From benefits in epilepsy, autism, and beyond, here are some of 2017’s biggest medical cannabis news stories. This installment covers insights relating to CBD, but tune in to the second part of this series for more discoveries uncovered in 2017.

Cannabidiol (CBD) passes stage 3 clinical trial for treatment of epilepsy in children.

Source: New England Journal of Medicine, May 2017

This one was big. One of the greatest limitations in the medicinal cannabis field is the lack of randomized double-blinded studies, the standard in clinical research. This limitation is often the basis of the opposition’s argument that there’s no strong evidence to support clinical cannabis use. But that argument was undermined by the successful trial of CBD treatment in children with epilepsy.

CBD reduced the median number of seizures each month by 39% compared to 13% for placebo-treated patients.

Scientists studied the effect of CBD (Epidolex developed by GW Pharmaceuticals) on epileptic seizures in patients with Dravet syndrome. Dravet syndrome is a severe epileptic childhood disorder caused by genetic mutation that reduces brain inhibition and leads to frequent and uncontrollable seizures. Traditional anti-epileptic medications are largely ineffective at preventing seizures in Dravet syndrome, but anecdotal reports from parents of children with the condition suggest that CBD-rich cannabis effectively reduces seizures.

The researchers found that orally-consumed CBD oil over a 14-week treatment period was an effective anti-epileptic treatment in these patients, reducing the median number of seizures each month by 39% compared to 13% for placebo-treated patients. Further, these anti-epileptic benefits were achieved with only minimal side effects, of which diarrhea and drowsiness were the most reported. While these could be problematic in their own right, they beat having seizures and many of the side-effects from traditional anti-epileptic strategies.


Cannabis and Epilepsy Treatment

Because CBD was used as an add-on therapy to the patients’ other anti-epileptic medications, one of the limitations of this study was not being to identify if CBD on its own reduced seizures, or if its anti-epileptic abilities were through interaction with other medications.

Nonetheless, this study’s double-blinded design was a substantial improvement over earlier assessments and benefited from a large sample size (61 received CBD, and 59 received placebo). Previous CBD trials found that it effectively reduced seizures in other drug-resistant forms of epilepsy, but the conclusions of these studies were weakened by their open-label nature, which allowed patients and doctors to be aware they were taking CBD and permitted bias.

This is the largest and most successful clinical trial to-date to demonstrate the medicinal benefits of CBD, and it will likely convince many clinicians to consider CBD for treating the 20% of epileptic disorders that are poorly controlled by traditional anti-epileptic drugs.

Add autism to the list of CBD’s medicinal benefits.

Source: Proceedings of the National Academy of Sciences, October 2017

Autism is often the result of too little inhibition in the brain, which leads to heightened sensitivity to stimuli (such as lights, sounds, touch, and smells) and abnormal social behavior. Epilepsy can also result from too little brain inhibition, and it’s common for individuals on the severe end of the autism spectrum to also have epilepsy. Scientists then may study both epilepsy and autism that are caused by the same DNA mutation.

Soon after the exciting clinical data demonstrating CBD’s effectiveness at reducing seizures in children with drug-resistant epilepsy, University of Washington scientists published a report demonstrating CBD’s effectiveness in a mouse model of epilepsy and autism.


How Does Cannabis Consumption Affect Autism?

As described above, one of the limitations of the clinical study of CBD in patients with Dravet syndrome is that, for ethical reasons, patients remained on their anti-epileptic medications; CBD was used as an add-on therapy, leading skeptics to posit that CBD’s anti-epileptic effects were in fact mediated by an interaction between CBD and other medications. To assess if CBD had anti-epileptic effects on its own in drug-resistant epilepsy, scientists tested CBD’s effects in mice with the same genetic mutation as humans with Dravet syndrome.

CBD increased the mice’s preference for spending time interacting with other mice and reduced the number of social anxiety-like behaviors.

In these epileptic mice, scientists confirmed that CBD, by itself, was sufficient to reduce seizures. Further, it was revealed that CBD rescues deficits in brain inhibition by blocking the activity of a brain receptor called GPR55. Now that CBD’s anti-epileptic effects are better understood in the brain and have been observed in humans and rodents, there’s an especially compelling case for clinical use of CBD in treating drug-resistant epilepsies.

But it doesn’t end there.

In addition to epilepsy, children with Dravet syndrome and other epileptic disorders often have autism. Unfortunately, the phase III clinical trial of CBD’s efficacy on seizures wasn’t able to simultaneously address autism-like social deficits in these individuals. However, University of Washington scientists looked at CBD’s impact on autistic-like social deficits, and they revealed that CBD normalizes social behavior in mice. CBD increased the mice’s preference for spending time interacting with other mice and reduced the number of social anxiety-like behaviors. Critically, this improvement occurred even after the mice had undergone numerous seizures, which highlights its medicinal potential at any age.


CBD (cannabidiol): What does it do and how does it affect the brain & body?

This was the first controlled study to demonstrate CBD’s ability to treat autistic-like social behaviors. CBD’s ability to improve symptoms of autism, even if it’s used in late developmental stages or adulthood, provides strong justification for the first human clinical trial to test cannabis oil in the treatment of autism, which is currently being conducted in 120 Israeli patients.

Addressing 2016’s biggest health scare: Does CBD turn into THC in our stomach?

Source: Journal of Pharmaceutical and Biomedical Analysis, available online December 2017

In 2016, a report claiming that CBD gets converted to THC in the stomach raised fear among proponents and patients. CBD has been emerging as a powerful medicinal tool for treating numerous disorders in children, adolescents, and adults. However, if CBD were to be converted to THC, this could negatively impact brain development in children and adolescents and induce side effects in adults.

Since that report, many have stated the obvious: If CBD gets converted to THC, then patients that consume large doses of CBD should experience THC-like effects. But they don’t! This simple observation prompted many to speculate that the conversion of CBD to THC was an artifact of the experimental conditions which were conducted in a petri dish and not a living creature.

To address whether CBD gets converted to THC in a living animal, scientists in Italy dosed rats with a high concentration of CBD and measured cannabinoids in the blood. Neither THC nor its metabolites were detected. These findings support the conclusions from behavioral studies in humans and animals that CBD does not convert to THC in the stomach in any meaningful amount. So in 2018, rest assured that you can attain CBD’s medicinal benefits without the potential risk of THC exposure.

Eager for more of 2017’s most compelling cannabis research? Stay tuned for part two, where we dive into more good news brought forth by the scientists and researchers working boldly in the cannabis space.

Lead Image: Kkolosov/iStock

Josh Kaplan's Bio Image

Josh Kaplan

Josh Kaplan, Ph.D., is an Assistant Professor of Behavioral Neuroscience at Western Washington University. He is a passionate science writer, educator, and runs a laboratory that researches cannabis' developmental and therapeutic effects.

View Josh Kaplan's articles

3 part series

  • amisjihad

    I live in Switzerland and one can purchase CBD oil from most kiosks (basically news stands) and grocery stores around the country. Most of the Spar grocery stores, at the checkouts, have posters showing the various varieties and strengths that you can purchase. As most of us know America (yes I am American) is still living in the 1950’s when it comes to health care and taking care of its people. In America tobacco and alcohol are acceptable but if caught with medicinal cannabis it could land someone in jail for a very long time.

    • Annie in NM

      Thanks to big money controlling everything, especially the politicians who have the power to create change, but don’t.

  • Concerned Citizen

    CBD oil has helped my wife’s sleep quality and Premenstrual Symptoms (PMS). She uses the highest quality CannazALL capsules.

  • Steve Martling

    I hope to Hell it gets rushed to legality here in CA. I don’t want a scheduled brain op for intractable complex Epilepsy….😔

    • Tayyab Pirzada

      It’s already legal in CA for medical use, friend. I’d advise getting a prescription for medical cannabis.

  • Jane

    That’s a great article on CBD science! Sometimes it’s not easy to say if the companies are telling the truth about the scientific support of the products, but I personally found this a great sources of CBD products and would advocate for the quality of their products based on personal experience.

  • Lisa Jacobs

    Where can I buy goid quality cbd oils

    • I know people should not advertise but I go to a very trustworthy company called AnnCannMed to buy CBD Oil. My life, appetite, and overall happiness has improved a lot. You can checkout their site for more infor and medical purchase.

  • CBD Rich Oil from ANNCANNMED has saved my life. No anxiety any more and i am able to sleep a lot easier. It’s amazing to see the many different benefits of CBD and i am glad that people are finally speaking out on it!

  • Mike Benson
  • Moira Faulds

    I have noticed a huge difference with my painful inflammation (arthritis-related condition) and also a mood lift that I didn’t expect and was a delightful surprise. I have also noticed that, with pain dealt with more effectively by CDB, I am actually smoking and ingested less marijuana and have a better quality of life. I highly recommend 🙂 Canadian Moira XO