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The Best Cannabis Strains for Depression

(Gillian Levine for Leafly)

Whether or not you agree with it, a lot of people choose to self-medicate depression symptoms with cannabis. Recent studies even suggest a link between depression and the body’s endocannabinoid system, which would help explain why so many favor cannabis over legal pharmaceutical alternatives.

You may be of the mindset that any ol’ strain will do and that its genetic background doesn’t matter. For people without legal access to cannabis, this mentality may not even be a choice (for right now, at least). But if you have access to a menu of different choices, you may have noticed that some strains are in fact better-suited for depression symptoms than others. Why is that?

The answer lies in a strain’s chemical profile. Look beyond the THC content of a strain and you’ll see a rich composition of cannabinoids and terpenes, compounds that offer a myriad of therapeutic properties. Depending on the nature of your symptoms, different strains offer different solutions. For more options, check out all strains in our database rated highly for depression relief.

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Cannabis Strains to Help Improve Your Mood

Strains high in the terpene limonene are typically great choices for mood elevation. Limonene has a sweet citrus smell, so try following your nose if your dispensary doesn’t offer chemical profiles.

Leafly Jack Herer cannabis strain tileLeafly Jack Herer cannabis effects

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Jack Herer is a strain cherished for its uplifting qualities that inspire happiness and creativity. A look at Jack Herer’s chemical profile shows high levels of limonene and pinene, terpenes that boost mood and focus respectively.

Leafly Pineapple Express cannabis strain tileLeafly Pineapple Express cannabis effects

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Pineapple Express takes you on a one-way trip to your happy place where energy and bliss are simultaneously awakened by sweet fruity flavors.

Leafly Harlequin cannabis strain tileLeafly Harlequin cannabis effects

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Harlequin, with its 1:1 ratio of THC and CBD, is the perfect solution for anyone needing a clear head alongside their depression relief. CBD helps counteract the sometimes anxiety-inducing effects of THC, so if you’re prone to nerves, Harlequin is for you.

Cannabis Strains to Combat Fatigue and Disinterest

Sativas have lighter, more energetic effects than indicas, but be mindful of the fact that some sativa strains can induce anxiety. Strains rich in pinene can help promote focus, and this terpene is usually more concentrated in pine-scented strains.

Leafly Cannatonic cannabis strain tileLeafly Cannatonic cannabis effects

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Cannatonic is another high-CBD strain that delivers you to bliss without the anxiety often associated with high-THC strains. Its interplay of CBD and THC allow you through your day with a heightened mood and mental clarity.

Leafly Cinex cannabis strain tileLeafly Cinex cannabis effects

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Known for its creative stimulation and lightweight effects, Cinex can rekindle interest in the hobbies you love (and maybe in the ones you didn’t know you loved!).

Leafly XJ-13 cannabis strain tileLeafly XJ-13 cannabis effects

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With its uplifting citrusy aroma, the sativa-dominant XJ-13 can reintroduce a bright lining to even the simplest things, and is typically clear-headed enough to be used any time of the day.

Cannabis Strains to Help Curb Anxiety

THC is a common culprit of anxiety, so if you’re dealing with a high-THC strain, be sure to dose modestly. Alternatively, try a strain with lower levels of THC and/or a more robust CBD profile.

Leafly Lavender cannabis strain tileLeafly Lavender cannabis effects

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Lavender balances cerebral bliss with physical relaxation alongside a sweet and calming lavender aroma.

Leafly Sour Tsunami cannabis strain tileLeafly Sour Tsunami cannabis effects

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Sour Tsunami and its high-CBD content makes it a great option for anxiety-prone individuals, particularly those sensitive to THC’s intoxicating effects.

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Cannabis Strains to Help Address Appetite Loss

On the one hand, THC is an adept appetite stimulant, but can also exacerbate anxiety. The below strains are great choices for coercing appetite without triggering unwanted anxiety-related side effects.

Leafly Granddaddy Purple cannabis strain tileLeafly Grandaddy Purple cannabis effects

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Granddaddy Purple is an indica strain that awakens appetite without worsening anxiety, but this strain is best saved for the evening if chronic fatigue is a problem for you.

Leafly Lemon Kush cannabis strain tileLeafly Lemon Kush cannabis effects

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Lemon Kush stimulates hunger with the added bonus of light, uplifted effects. With its sweet lemony aroma, Lemon Kush staves off stress while leaving your senses sharp.

Cannabis Strains to Help Battle Insomnia

Indicas are the best combatant of insomnia, as they tend to be high in the sedating, musky-smelling terpene myrcene.

Leafly Blackberry Kush cannabis strain tileLeafly Blackberry Kush cannabis effects

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Blackberry Kush is a perfect late-night strain that brings a heavy, peaceful calm to both mind and body.

Leafly Tahoe OG Kush cannabis strain tileLeafly Tahoe OG Kush cannabis effects

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Tahoe OG Kush quickly crushes sleeplessness while keeping floating thoughts anchored in a relaxed mindset.

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Explore More Cannabis Strains Based on Your Depression Symptoms

Use the Leafly Explorer to find more cannabis strains that may help curb your symptoms of depression: