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Growing

David Downs’ sickest weed genetics picks of 2025

David DownsLast updated February 21, 2025
Over 50 sick seed and clones picks across 6 categories await you below. (Courtesy Compound Genetics)
Over 50 sick seed and clones picks across 6 categories await you below. (Courtesy Compound Genetics)

Sure, it’s the cold winter of our discontent, but take heart— the Earth has begun tracking back toward the sun, and the days grow longer again.

Start dreaming today of a dank pound or two come Thanksgiving, then start sourcing your seeds and clones, sketching a gardening plan, and calendaring your harvest.

I know I am. As Leafly News’ senior editor and co-author of the best-selling book ‘Marijuana Harvest,’ I pop beans, soak up strain trends, as well as judge and report on award-winners.

Now it’s again time to wring out all that knowledge to help you plant some winners. Here are over 50 sick genetics picks in 6 categories that we’d be stoked to garden with you.

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Jump to a strain category
  • Candies
  • Desserts
  • Zs
  • OGs and Sours
  • Hashers
  • Sativas
  • Bonus round: Purps

Candies

Exotic Genetix Bluezy. (Courtesy Exotic Genetix)
Exotic Genetix Bluezy. (Courtesy Exotic Genetix)

We lead off with the flavor that controls the market coast to coast—dubbed ‘candies’ for their candy sweetness, but also their full-bodied dankness often referred to as ‘gas’. Based around Lemon Cherry Gelato and kin, these indica hybrids sell themselves, and keep the commercial market humming.

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Compound Genetics

Chrome Dome (Lemonheadz x Eye Candy). Compound Genetics adds more flavor to its blingiest buds. “The nose leans towards sweet lemon zest and lemon-scented cleaning products with an effervescence akin to Sprite.”

Chrome Dome takes its bling from Eye Candy and adds more lemon. (Courtesy Compound Genetics)
Chrome Dome takes its bling from Eye Candy and adds more lemon. (Courtesy Compound Genetics)

Exotic Genetix

Bluezy (Zoap x Blueberry Bang Bang). Washington breeder Exotic Genetix has worked the hot strain Zoap with the hot flavor trend blueberry. Exotic Genetix writes: “One of my absolute favorite looks on a flower! The colas get so dark in places that they begin to take on a crazy blue sheen. … These juicy goodies make you think you are inhaling a complex basket of different fuels, even somewhat reminiscent of very aromatic soaps to the nose.”

Purple City Genetics

G-Runtz (Pre-64 Runtz x Gush Mints). All the hype of Runtz with a much bigger yield, from the Oakland cloning powerhouse.

Related
Leafly Buzz: 12 hot strains to smoke in 2025

Tiki Madman

Jelly Rain (Jealousy x Candy Rain); Party Boy (Zoap x Z Rain). Tiki Madman dominates the sweets game and these crosses of Leafly Strain of the Year 2022 Jealousy, or 2025 Leafly Buzz Strain Zoap will make ‘em go crazy.

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Phinest

Oakland Runtz #25 (Don Merfo LCG#7 x Lemon Cherry Gelato); K-Whip (Pineapple Dolomite x Shady Apples). The Sacramento clone kings at Phinest keep farmers fed with their candy selections this year.

Oakland Runtz #25. (Courtesy Phinest)
Oakland Runtz #25. (Courtesy Phinest)

Cannarado Genetics

Lemon Zawtz (Lemon Tree x Zawtz x Zawtz Bx1). Colorado’s biggest breeder writes “Lemon candy chem best describes this hybrid. Good yields with mouth-staining terps!”

Ethos Genetics

Lemon Cherry Pie R1 (Candy Store #25 x Cherry Pie). Colorado breeder Ethos sells this ‘reversal’ strain that has “sharp lemon upfront. Sweet cherry tones. Muted pine.”

James Loud Genetics

Permanent Midnight (Permanent Marker x Double Lemon Cherry) from this Hayward, CA breeder includes Leafly Strain of the Year 2023.

Related
Spark joy with Super Boof—Leafly Strain of the Year 2024

Crockett Family Farms

Tap into the Trop Cherry wave that helped power Super Boof to Leafly Strain of the Year 2024. Get Crockett’s Blood Cherry (Blood Orange x Trop Cherry) crosses like Cherry Clem (Clementine x Blood Cherry), and Fruity Loopz (Clementine x Blood Cherry).

Happy Dreams

Cherrilicious (Cherry Frosting x Cherry GAS). The masses love cherries and award-winning Happy Dreams contributes to filling that need.

Seattle Chronic

ZodiaK lookin’ killer. (Courtesy Seattle Chronic)

Up in Washington, check out ZodiaK (MelvinZ x Candybreath F2 #62) for garlic, grapes, melon, and funk. A collaboration with Magnetic Genetics

Shop for seeds right on Leafly

Desserts

Tie Die (Jealousy x Sunset Sherbert). (Courtesy Cookies Seed Bank)
Tie Die (Jealousy x Sunset Sherbert). (Courtesy Cookies Seed Bank)

When we say ‘Desserts’ we mean Girl Scout Cookies-related strains, which continue to dominate year after year. No grow is complete without this powerful dynasty that includes Sherbert, Gelato, Runtz, and Gary Payton. Yes, ‘desserts’ cross over with candies, but they get more doughy, cookie, and cakey.

Karma Genetics

Pink Payton (Gary Payton x Pink Runtz). Gary Payton and Runtz is a combo that cannot miss among dessert fans.

Related
Sniff away, America—Permanent Marker wins Leafly Strain of the Year 2023

Umami Seeds

No Assist (Gary Payton x Zoda). This super-hot Southern California breeder is known for one-and-done strain releases. You’ll never see these back in stock from Umami when they sell out.

Seed Junky

Animal Tree (Lemon Tree x Animal Mints Bx1); Caribbean Breeze (Pineapple Fruz x (Biscotti x Sherb BX))

Cookies Seed Bank

Cookies logo: a white "C" with a curlycue at the top of the letter against a round blue background with a bite taken out of it like a cookie
(Courtesy Cookies)

Tie Die (Jealousy x Sunset Sherbet), Pink Runtz x Hollywood, Lemon Cherry Pop (Gastro Pop 5 X Double Lemon Cherry). You can’t talk about dessert strains without visiting Cookies’ very own seed bank.

Dewey Seed Co

Pink Drink (Island Cookies x (Sour Mango x Bahama)). Known for winning big at North West Leaf Bowls, Dewey strains are rooted in science.

Higher Heights

This Mendo breeder of rarities champions Pineapple Mojito (Carambola x Lemon Limez). Lemon Limez is (Sour Diesel x Biker Kush) x Key Lime Pie. Carambola is (Sunburn x Green Tea) x Brozé.


Zs

Exemplary Z. Grown indoors in living soil by MOCA Humboldt, CA. Hybrid. (David Downs/Leafly)
Exemplary Z. Grown indoors in living soil by MOCA Humboldt, CA. Hybrid. (David Downs/Leafly)

The Original Z remains tough to beat on the contest circuit, but it’s just the beginning of the tropical candy taffy tastes this year.

Dying Breed Seeds

Rainboz V.S. (Rainbow Rayz x OZ Kush). These magic beans run $500 per pack, hot dayam, but they can boost you into the front of the global flavor chase spawned by the Z strain.

Hendrx Nursery

SoHum Royal Blue Nerds. (David Downs/Leafly)
Small but mighty tasty: A Blue Nerds grown by SoHum Royal. (David Downs/Leafly)

Blue Nerdz (Runtz x Zkittlez). Created by Global Genetics LA—the flavor makes up for the yield on this hype cross. See also: Gelo Belts (Gelonade x Rainbow Belts 3.0). “Has the potential to replace Gelonade for commercial farmers. Potency and yield will dictate. Great clone!”

Archive Seeds

Zsunami. (Courtesy Archive Seed Bank)
Zsunami. (Courtesy Archive Seed Bank)

Zsunami (Zazul #5 x Moonbow 112 F2 #60). Archive Seeds’ Fletch writes, “Just give it a couple years, and you guys will be asking about it like the Rainbow Belts!”

Clearwater Genetics

Blue Nerds crosses; Cherry Chewbanger (Sherbanger 22 x Hi Chew 27) crosses. Clearwater cleared the field of competitors with their Mai Tai line. Don’t sleep on their Blue Nerds or Sherbanger work.

Biovortex

Cherry Lime Dogz. This cross is too long to name. And noted breeder Biovortex has been refining it for 8 years. He describes “a fermented cherry cola fizz with purple pixie stick and gas that smelled and tasted like some magical ambrosia reserved only for the gods.”

Cookies Seed Bank

ZZ4 ((GG4 x Zkittlez) x Medellin).

Capulator

Coolio (Cap Junky x Caps Frozen Oranges). Los Angeles titan Capulator recommends Coolio for its smell of “orange nail polish that takes your tastebuds to flavor town. … an incredibly uplifting and productive high that is great for focus and creativity.”

Get growing with Leafly

OGs and Sours

Gas Drop. (Courtesy Ziplock Seeds)
Gas Drop. (Courtesy Ziplock Seeds)

Are you longing for old-school OG Kushes and Sour Diesels? Start hunting for them—there are plenty of options.

Karma Genetics

Sour Fire Tahoe (Fire Tahoe x Karma Sour D bx2); Hayabusa OG (Race Fuel OG x Biker Kush). Karma Genetics has some of the best sours in the world.

Rebel Grown

Some protean OG and Sour traits on display from Rebel Grown. (Courtesy Rebel Grown)
Some ideal OG and Sour traits on display from Rebel Grown. (Courtesy Rebel Grown)

Get the latest Double OG Chem #15 x Double OG Sour F4, and ride the coattails of this back-to-back 1st place Sun Grown, and Breeders Cup Winners of the 2023 and 2024 Emerald Cup. “Flavor spectrums of gas and fuel beyond what you remember from the best OG Sour and Chems you reminisce about.”

Also, Double OG Chem #15 x Island Mtn Headband F4 for “super gassy nose, vigorous plants, chunky frosty flowers. This is what heavy gas smokers have been
searching for and missing.”

Mendo Dope (via Tangled Roots)

Heady OG Bx1. Grow this special 2024 Emerald Cup 1st Place Sungrown Personal & Best In Show overall winner of the entire competition. Mendo Dope says: “Heady OG has become one of our favorite creations. We have seen so many insane phenotypes both indoor and outdoor and they have all been our new favorite smoke.”

Archive Seeds

Holy Roller (Big Sur Holy Weed x Face Off OG); Duct Tape (GG4 x Dosidos). Gas and sour fans, strap in for Archive’s undeniably elite crosses of Face Off OG, or GG4.

Hendrx Nursery

Tire Fire OG ((OG Kush X Triangle Kush) X San Fernando Valley OG)). Gas lovers rejoice, this one smells like ammonia, butter, chestnut, earth, fuel, garlic, kush, rubber, skunk, woody, asphalt, and burnt rubber. Hendrx writes: “Bred by Russell from ChaScience. Best OG I have seen in 15 years. So consistent. Very easy to hunt. Consistent Gas. Picked a few winners. Heavily narcotic high. This is the youngest new phenotype at HENDRX right now. Has the biggest potential.”

Greenshock

Double Lanterns (Green Lantern x Long Valley Royal Kush x Double OG Chem)
Emerald Cup champ Greenshock is focused on fuel strains with this 1.7-1.9% caryophyllene flower. “Taste smells of skunk and gasoline.” Testing at 37% THC with total cannabinoid content at 44% total.

CHA Genetics

CHE Genetics’ Russel recommends Sour Dizzle (AJ’s Sour D x Lime Sour).

Ziplock Seeds

Gas Drop (Gas Face x Frosted Flakes). “Begins with strong gas notes that hit the palate with a pungent, cleaner-like aroma, followed by sharp diesel and sour undertones. … A crew favorite.”

Massive Creations

Shiloh Massive has some intriguing OG/Sour work this year with 97 Super Sour (818 Headband F4 x 97 Sierra Sour); and Kobayashi (818 Headband F4 x Marion Berry). Part of Shiloh’s new Si Lo Sabes line.

DNA Genetics

Kosher Kush. A classic, storied OG Kush that’s ready to grow.


Hashers

More and more flower goes straight into hash this year all around the world in grows big and small.

Masonic Seeds

Step into the hash game with the market-rattling bangers from Compton, CA’s Masonic Seeds. The Wilson, Banana God, and Ego Clash Bundle are all winners that don’t come cheap.

Biovortex

Banana Halo Halo ((Ice Cream Cake x Banana DOG) x Motor-G-nut). Selected by Yooper Crew for her extremely high hash yields. See also—Papaya Punch x G-Nut; Chemmy G.

Freeborn Selections

Turkey Bag (Animal Cookies x GMO x MeyerLemsky). Smells like turkey! “It sounds weird, but it’s so tasty. And it makes so much hash.”

Bodhi Seeds

Mule Fuel x 88G13HP. Stanky Mule Fuel and 1988 G-13 Hash Plant should yield some dank hashers.

3rd Coast Genetics

Investigate Michigan breeder’s hot ‘Black Truffle’ line with Solar Garlic (GMO x Black truffle); Rainbow in the Dark (Cadillac Rainbowz x Black Truffle); and Black Tar (Grease Monkey x Black Truffle).

Sativas

massive chunky nug in light and dark shades of green with dull orange hairs sitting in, and filling, the black lid of a jar
Blue Dream (David Downs/Leafly)

Lastly, we leave room for old-school strains that don’t yield a lot and take forever to finish. Sativas are perfect for home gardening where there’s no pressure of finishing early to make a payday.

Equilibrium Genetics

Panama Haze (Panama Red x Tom Hill Haze). A pine and floral 12-weeker that’ll warp you back to Woodstock. Panama Red is a sativa heirloom collected in Panama in the 1970s. Tom Hill Haze is a stable haze line bred in Mendocino by Tom Hill from Haze sourced in Amsterdam from Positronics Seeds in 1996.

Top Dawg Seeds

East Coast sour legends have a bunch of sours and crazy sativas for you. Sour Trinity (Trinity X Sour Diesel BX3); Sour 91 V2 (91 Chem X Sour Diesel F5); Nigerian Haze F3; Black Haze BX (Black Haze X Black Haze/Black A5 Piff); and Cross Bronx Haze (Tres Haze X NYC Haze).

Hendrx Nursery

XJ-13 (Courtesy of THC Designs)

XJ-13. Help bring back this big Jack variety, and put some pep in your step with XJ-13 from Northern California’s Henrdx Nursery.

Rebel Grown

Blue Dream. Grow a classic strain from a legendary breeder. Obviously not a pure sativa, but put in here with the hazes. DNA Genetics also has a Blue Dream.

TerpHogz

TerphogZ Geneticz seeds come in various elite flavors, for deliver in California. (Courtesy TerpHogz)
TerphogZ Geneticz seeds come in various elite flavors, for deliver in California. (Courtesy TerpHogz)

Red Skrrt-Banger (Skrrrt-Berry Zuava x Red Kachina 2.0). A new Terphogz X Conscious Genetics collaboration hits with “powerful gas, creamy citrus, and exotic funk.” This 60-40 sativa offers the latest from The Original Z crew.

Bonus round: Purps

Dramatic, dark, icy purple cannabis stays winning in gardens this year.

Atlas Seed

Atlas recommends Iced Sangria combining the bling and easy yield of Atlas Seed #1 (Oreoz) X Purple Punch.

Mass Medical Strains

Star Pupil. (Courtesy Mass Medical Seeds)
Star Pupil. (Courtesy Mass Medical Seeds)

Star Pupil (Thai x Afghani/Pakistani) remains the star of the show at this Massachusetts breeder. “Purple trichomes are common, and in cold her buds can actually go fully black in color!” Smell described as “perfume, grape, heavy, ‘purple’, skunky and thick.”


And that’s my sickest genetics picks of 2025 for your weed garden, featuring over 50 flavors in 6 categories. Still, I’ve just scratched the surface, so let us know in the comments what you’re stoked to grow.

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archivecannaradoCapulatorcompound geneticscookies seed bankcultivationdna geneticsexoticgardeninglemon cherry gelatomasonic seedsOG Kushpurple city geneticsSeed Junky Geneticsseedstiki madmanzkittlez
David Downs
David Downs
Leafly Senior Editor David Downs is the former Cannabis Editor of the San Francisco Chronicle. He's appeared on The Today Show, and written for Scientific American, The New York Times, WIRED, Rolling Stone, The Onion A/V Club, High Times, and many more outlets. He is a 2023 judge for The Emerald Cup, and has covered weed since 2009.
View David Downs's articles

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