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The best cannabis strains for depression

March 24, 2015
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Updated 10/1/19

Depression is a complex disorder, and cannabis is a complex plant. Research has yet to demystify the relationship between the two, and that’s an important consideration for those suffering from depression.

Despite these complexities, there are individuals who claim that cannabis helps them through depression. For some, cannabis can imbue the mind with an elevated sense of engagement and motivation. It can stimulate hunger, conversation with friends, and interest in hobbies and creative escapes. We highly encourage you to communicate with your medical professional to determine how cannabis may interfere with your current treatments and medications.

Related

Does cannabis interact with antidepressants?

It’s important to recognize that cannabis doesn’t serve everyone. If you find that cannabis is becoming a burden on your journey, it’s okay to set it aside temporarily or for the long haul.

And finally, remember that not all cannabis strains are equal:

  • THC strains are the most common. They produce the euphoric high associated with cannabis, along with appetite stimulation. Some people find THC’s effects to pique curiosity and motivation, but others may find that it worsens anxiety. For high-THC strains, look for strains with diamonds below.
  • CBD strains are less common. Because their effects range from no high at all to mild intoxication, these strains are often preferred by those who are new to cannabis or anyone looking to avoid the anxious side effects of THC. For CBD strains, look for strains with circles below.

As you explore new cannabis strains, pay attention to the terpenes (colors) that make up your favorites. These aromatic compounds are important to your experience as they shape the aroma, flavor, and potentially even the effects associated with different strains.

Related

Try these limonene cannabis strains for anxiety, depression, and stress relief

Cinex

cinex cannabis strain

Primary terpenes: Limonene, caryophyllene, pinene

Cannabinoid profile: THC-dominant

Known for its creative stimulation and lightweight effects, Cinex can rekindle interest in the hobbies you love (and maybe in the ones you didn’t know you loved!). Cinex leads with the citrusy terpene limonene, which is being studied for anxiety and depression relief.

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Jack Herer

jack herer cannabis strain

Primary terpenes: Terpinolene, caryophyllene, pinene

Cannabinoid profile: THC-dominant

Jack Herer is a strain cherished for its uplifting qualities that inspire happiness and creativity. With an aroma of sharp pine and freshly cut wood, Jack can provide a sense of comfort and motivation on low days.

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Harlequin

harlequin cannabis strain

Primary terpenes: Myrcene, pinene, caryophyllene

Cannabinoid profile: Balanced THC/CBD

Harlequin balances the benefits of both THC and CBD, resulting in a strain that can deliver relief alongside a clear head. CBD helps counteract the sometimes anxiety-inducing effects of THC, so if you’re prone to nerves, Harlequin is for you.

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Granddaddy Purple

granddaddy purple cannabis strain

Primary terpenes: Myrcene, caryophyllene, pinene

Cannabinoid profile: THC-dominant

Granddaddy Purple is a soothing strain that can awaken appetite and encourage a sense of serenity throughout the mind and body. This strain is best saved for late nights when you need a little help finding a cool, calm headspace before bedtime.

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Cannatonic

cannatonic cannabis strain

Primary terpenes: Myrcene, pinene, caryophyllene

Cannabinoid profile: Balanced THC/CBD

Cannatonic is another high-CBD strain that delivers you to bliss without the anxiety often associated with high-THC strains. If THC makes you feel sluggish or hazy, consider the clarity and unencumbered relief Cannatonic offers many consumers.

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XJ-13

xj-13 cannabis strain

Primary terpenes: Terpinolene, caryophyllene, pinene

Cannabinoid profile: THC-dominant

With its bright citrusy aroma, XJ-13 has a way of throwing color back into the world and sharpening the senses. If you’re looking to invite curiosity, creativity, or a social spark back into your mind, you might consider this sweet, uplifting strain.

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Blackberry Kush

blackberry kush cannabis strain

Primary terpenes: Myrcene, limonene, caryophyllene

Cannabinoid profile: THC-dominant

Can’t seem to shake those late-night thoughts keeping you up? Let Blackberry Kush ease you into sleep with its meditative tranquility that helps you find stillness in mind and body.

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Explore more cannabis strains for depression

Use the Leafly Explorer to find more cannabis strains that have been rated highly by other Leafly users for related symptoms:

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Bailey Rahn's Bio Image

Bailey Rahn

Bailey is a senior content manager at Leafly, specializing in strains and health. She's spent 7+ years researching cannabis products, spreading patients’ stories, and exploring healthy ways of integrating cannabis into daily life.

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